Procaine Penicillin 400.000 I.U.
Vials
Parenteral penicillin Composition:
Each vial contains:
Procaine penicillin G 300,000 I.U.
Penicillin G Sodium 100,000 I.U.
Properties:
Procaine penicillin has mainly bactericidal action against a wide range of Gram-positive and Gram-negative organisms. When Procaine penicillin is given by I.M. injection, it forms a depot from which it is slowly released and hydrolyzed to benzyl penicillin.
Benzyl penicillin is a highly potent antibiotic, which interferes with the synthesis of the bacterial cell wall ; it rapidly appears in the blood following I.M injection. It enters most tissues, lesions and serous cavities, small amounts enter bone marrow, abscesses, pleural fluid, and C.S.F unless the meninges are inflamed. It crosses the placenta and small amounts are secreted in the milk. It is rapidly excreted in the urine.
Procaine penicillin is not known to be harmful during pregnancy or lactation. Indications & usage:
Treatment of infections caused by micro-organisms that are highly sensitive to penicillin as Streptococcal (including pneumococcal infection and streptococcal endocarditis), gonococcal and meningococcal and also for Anthrax, diphtheria, gas-gangrene, leptospirosis and treatment of lime disease in children.
Treatment of early syphilis. Contra- indications:
History of hypersensitivity to penicillins. Side effects:
Hypersensitivity reactions like skin rashes and urticaria may occur.
Diarrhea and antibiotic-associated colitis may rarely occur. Drug interactions:
Probenicid and some non -steroidal anti - inflammatory agents
prolong the half -life of benzyl penicillin by competing with it for
renal tubular secretion.
Some bacteriostatic agents such as chloramphenicol interfere with
active bacterial growth and inactivate the drug .
Benzyl penicillin may interfere with some diagnostic tests such as those for urinary glucose using copper sulphate, and some tests for urinary or serum protein. Warnings & precautions:
Caution is required when using Procaine penicillin in the following cases:
Known history of allergy.
Patients with impaired renal function (dose should be reduced). Dosage & administration:
1 vial, each 12 or 24 hours by I.M injection according to the case . Packing:
Carton box of 50 vials. Storage :
Store at a temperature not exceeding 30 oc . | 
