Composition:
Cidophylline 2 ml: Each ampoule (2 ml) contains:
Dihydroxypropyl theophylline (Diprophylline) 250 mg

Cidophylline 5 ml: Each ampoule (5 ml) contains:
Dihydroxypropyl theophylline (Diprophylline) 300 mg

Properties:
Cidophylline is a derivative of theophylline having similar pharmacological action. It has two distinct actions in the airways of patients with reversible obstruction which are:
- Smooth muscle relaxation (i.e. bronchodilatation) which is mediated by inhibition of phosphodiesterase (PDE).
- Suppression of the response of the airways to stimuli (i.e. non-bronchodilator prophylactic effects).

Indications & usage:
Cidophylline is indicated for the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung disease as emphysema and chronic bronchitis.

Contra-indications:
Known hypersensitivity to theophylline or theophylline derivatives.

Side effects:
Gastro-intestinal disturbance.
Tachycardia and palpitations.
CNS stimulation: arrhythmias and insomnia.
Convulsions may rarely occur.

Drug interactions:
Diprophylline is not metabolised by hepatic microsomal cytochrome P450. So, it does not exhibit the numerous interactions seen with theophylline
Probenicid may decrease clearance of diprophylline.

Warnings & precautions:
* Cidophylline should be used cautiously in these cases:
Renal impairment.
Hyperthyroidism.
Peptic ulcer.
Fever.
Epilepsy.

Cidophylline should be used cautiously during late pregnancy and lactation to avoid
neonatal irritability or apnea that may occur.

Dosage & administration:
250 -500 mg injected slowly I.M every 6 hours (Do not exceed 15 mg/kg every 6
hours).

Packing:
Box of 6 ampoules of Cidophylline 2 ml or Cidophylline 5 ml.
Box of 100 ampoules of Cidophylline 2 ml or Cidophylline 5 ml.

Storage :
Store at room temperature

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