Antiashmatic & bronchodilator
Cidophylline 2 ml: Each ampoule (2 ml) contains:
Dihydroxypropyl theophylline (Diprophylline) 250 mg
Cidophylline 5 ml: Each ampoule (5 ml) contains:
Dihydroxypropyl theophylline (Diprophylline) 300 mg
Cidophylline is a derivative of theophylline having similar pharmacological action. It has two distinct actions in the airways of patients with reversible obstruction which are:
- Smooth muscle relaxation (i.e. bronchodilatation) which is mediated by inhibition of phosphodiesterase (PDE).
- Suppression of the response of the airways to stimuli (i.e. non-bronchodilator prophylactic effects).
Indications & usage:
Cidophylline is indicated for the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung disease as emphysema and chronic bronchitis.
Known hypersensitivity to theophylline or theophylline derivatives.
Tachycardia and palpitations.
CNS stimulation: arrhythmias and insomnia.
Convulsions may rarely occur.
Diprophylline is not metabolised by hepatic microsomal cytochrome P450. So, it does not exhibit the numerous interactions seen with theophylline
Probenicid may decrease clearance of diprophylline.
Warnings & precautions:
* Cidophylline should be used cautiously in these cases:
Cidophylline should be used cautiously during late pregnancy and lactation to avoid
neonatal irritability or apnea that may occur.
Dosage & administration:
250 -500 mg injected slowly I.M every 6 hours (Do not exceed 15 mg/kg every 6
Box of 6 ampoules of Cidophylline 2 ml or Cidophylline 5 ml.
Box of 100 ampoules of Cidophylline 2 ml or Cidophylline 5 ml.
Store at room temperature