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Main » Photo album » Pharmaceuticals photos » Plemazol
Tablets – Syrup – Oral drops - Ampoules

Plemazol tablets: Each tablet contains 10 mg metoclopramide Hcl.
Plemazol syrup: Each teaspoonful (5 ml) contains 5 mg metoclopramide Hcl.
Plemazol oral drops: Each 1 ml (15 drops) contains 1 mg metoclopramide Hcl.
Plemazol ampoules: Each ampoule (2 ml) contains 10 mg metoclopramide Hcl.

Plemazol contains metoclopramide which stimulates the motility of the upper gastrointestinal tract without stimulation of gastric, biliary or pancreatic secretions. It relaxes the pyloric sphincter and the duodenal bulb. So, increases peristalsis and results in acceleration of gastric emptying. The anti-emetic properties of plemazol results from antagonizing central and peripheral dopamine receptors.

Indications & usage :
Plemazol is effective in the prevention and treatment of nausea and vomiting associated with the following:
Gastrointestinal disorders.
Post-operative nausea and vomiting.
Migraine attacks.
During pregnancy (second line treatment).
Emetogenic cancer chemotherapy.
Diabetic gastric stasis.

Plemazol is indicated as an accessory treatment for adults with symptomatic gastro-esophageal reflux.
Plemazol is helpful in radiological examination of stomach and/or intestine.
Plemazol is also helpful to facilitate bowel intubation in adults and children.
Plemazol can be used to improve gastrointestinal symptoms in patients with
anorexia nervosa.
Plemazol is used as adjunct treatment of gastric and duodenal ulcers and hiccups.

Gastrointestinal obstruction , perforation or hemorrhage.
(3-4) days after gastrointestinal surgery.
Hypersensitivity to metoclopramide.

Side effects :
Extrapyramidal effects (especially in children and young adults) may occur
as acute dystonic reactions.
Tardive dyskinesia may occur on prolonged use.
Transient feeling of anxiety, restlessness followed by drowsiness may occur
with rapid undiluted I.V. administration.
Transient hyperprolactinaemia may occur
Neuroleptic malignant syndrome may rarely occur.
Nausea and bowel disturbances, primarily diarrhea may occur.

Drug interactions:
The effects of Plemazol on GIT motility are antagonized by anticholinergic
and narcotic analgesics.

Plemazol can diminish the absorption of drugs from stomach as digoxin, and
enhance rate of absorption of drugs from intestine as acetaminophen and

Warnings & precautions :
Caution is required in the following cases:
Hepatic or renal impairment.
Hypertension and elderly.
Patients under 20 years: dose should be determined on body- weight basis.
Pregnancy and lactation: Plemazol should be used under close
medical supervision.
Epileptics or patients receiving other drugs which are likely to cause
extrapyramidal reactions.

Metoclopramide may mask underlying disorders such as cerebral irritation.

Dosage & administration:
Daily dose of metoclopramide should not normally exceed 0.5 mg/kg particularly for children and young adults.

By oral, IM or IV injection route:
* Up to 1 year: 1 mg (15 drops) twice daily.
* 1-3 years: 1 mg (15 drops) 2-3 times daily.
* 3-5 years: 2 mg (30 drops) 2-3 times daily.
* 5-9 years: 2.5 mg (½ teaspoonful) 3 times daily.
* 9-19 years: 5 mg (1 teaspoonful) 3 times daily.
* Adults: 10 mg (1 tablet) 3 times daily.

For diagnostic procedures:
As a single dose 5-10 minutes before examination administered as follows:
Children under 3 years: 1 mg
3-9 years: 2 mg
9-14 years: 5 mg
Adults 14-19 years: 10 mg
Above 19 years: 10-20 mg

Plemazol tablets: Box of 1000 tablets (100 strips of 10 tablets each).
Plemazol syrup: Bottle of 120 ml.
Plemazol oral drops: Bottle of 20 ml.
Plemazol ampoules: Box of 100 ampoules.

Storage :
Store at room temperature (15-30) oc .

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Date: 2010-04-14 | Tags: Plemazol | Added by: Modajaa
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