Laxel Effervescent salt Laxative and cholagogue Composition : Each 100 g contains : Disodium hydrogen phosphate 7.810 gm Sodium sulphate 15.620 gm Magnesium sulphate 15.620 gm Saccharin sodium 0.120 gm Effervescent base to 100.000 gm Properties : Laxel is a mixture of salts prepared in a nicely flavored , easily soluble , effervescent granular form . The main ingredients include magnesium sulphate , the salt with a specific cholagogue action in the drainage of the biliary passages . This action is achieved by direct relaxation of the sphincter of the common bile duct , simultaneously with contraction of the gall bladder this action allows a direct flow of the bile into the duodenum , thus preventing stasis and so safe guards against infection and stone formation . Laxel also contains sodium sulphate and sodium phosphate , both are poorly absorbed salts which retain water in the intestinal tract and produce a mild laxative effect . With the ensured flow of bile , this regulates the activity of the bowels and ensures better digestion and more complete evacuation . Indications & usage : - Chronic cholecystitis . - Constipation , ( occasional or habitual ). Contra-indications : - Addison's disease . - Osteomalacia . - Infected urolitheasis . - Long term treatment of patients with severe renal impairment - Congestive heart failure , acute dehydration and oedema . - In patients with gastrointestinal obstruction , inflammatory bowel disease , Acute pancreatitis , hypoparathyroidism and severe adrenal insufficiency . Side effects : - Nausea , vomiting , or diarrhea may occur . - Hypermagnesaemia is uncommon after oral administration except in renal impairment . Drug interaction : - Magnesium salts may decrease the absorption and the therapeutic effect of aminoquinolines ( eg. chloroquine ) , nitrofurantoin , tetracyclines and biphosphonate . - Antacids containing Aluminum or Calcium , and Iron containing medications may bind to phosphate and prevent its absorption . - Acidification of urine due to phosphates may increase elimination and decrease the therapeutic effect of anorexiants and sympathomimetic drugs , and may increase bioavilability of chlorpropamide and enhance the hypoglycemic action . Warnings & precautions : - Give with caution to patients with hyperphosphatemia and hypertension . - Chronic diarrhea due to long term administration may result in electrolyte imbalance . - Caution should be taken in patients receiving diuretics , in elderly, debilitated patients and those in pre –existing electrolyte disturbance . During pregnancy , lactation and in pediatrics less than 4 years use only as directed by physician . Dosage & administration : One packet in half a glass of water in the morning. This dose may be repeated twice or more daily before meals. Packing : Box of 12 packets each of 5 gm . Storage : Store at a temperature not exceeding 30 oc , and R.H less than 70 % . |