Isocid 50 : Each tablet contains 50 mg Isoniazid.
Isocid 100 : Each tablet contains 100 mg Isoniazid.
Isocid forte: Each tablet contains 200 mg Isoniazid.
Isocid is a highly effective anti-tuberculous drug. It should always be included in
any anti-tuberculous regimen unless there is a specific contra-indication.
Isocid kills actively growing tubercle bacilli by inhibiting the biosynthesis of
mycolic acids which are major components of the cell wall of Mycobacterium
Indications & usage:
-Treatment of tuberculosis:
Isocid is the drug of choice for tuberculosis infection in both initial and continuation phase regimen. It is used in combination with Rifampicin, Pyrazinamide and Ethambutol to avoid development of microbial resistance.
Isocid is administered daily for 6 months in case of patients at high risk (e.g.: those who have evidence of latent tuberculosis or who receive immunosuppressant).
Drug induced liver disease.
Severe hepatic damage.
History of severe hypersensitivity reactions.
Peripheral neuritis is the only common side effects that occur with high doses and more likely, where there are pre-existing risk factors.
This side effect can be prevented by taking Pyridoxine prophylactically from the start of treatment.
Other rare side effects include:
* Hypersensitivity reactions (fever, erythema multiforme, …. …).
* Hepatitis (especially over the age of 35 years).
* Optic neuritis.
* Psychotic episodes.
* Blood disorders (agranulocytosis, hemolytic anemia).
* GIT disturbance ( nausea, vomiting, constipation & dry mouth).
Isocid enhances the effect of antiepileptic drugs as Carbamazepine, Ethosuximide and phenytoin.
Isocid increases plasma concentration of Theophylline.
Isocid decreases plasma concentration of Ketoconazole.
Carbamazepine may increases hepatotoxicity of Isocid.
Warnings & precautions:
Isocid should be used cautiously in the following cases:
Hepatic or renal impairment.
States that may increase risk of peripheral neuritis as (alcohol dependence, malnutrition, diabetes mellitus, HIV infection).
Slow acetylator status (increased risk of side effects).
Pregnancy and breast-feeding.
History of psychosis.
Dosage & administration:
Isoniazid is used in combination with other anti-tuberculous drugs in a regimen of two phases: 2-months initial phase and 4-months continuation phase.
Adult : 300 mg daily.
Child : 5 -10 mg/kg B.W. daily (maximum 300 mg daily)
Adult and child: 15 mg/kg B.W. (maximum 900 mg) three times a week.
Isoniazid is administered once daily for 6 months as follows:
Adult: 300 mg daily.
Child: 10 mg/kg B.W. daily
Box of 100 or 200 or 500 tablets
( 10 or 20 or 50 strips each contains 10 tablets ).
Store at room temperature .