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Main » Photo album » Pharmaceuticals photos » Hi-flucil
Hi-flucil
Capsules, Vials
Broad spectrum antibiotic(penicillins combination)

Composition:
Hi-flucil capsules: Each capsule contains:
Amoxycillin (as trihydrate ) 250 mg
Flucloxacillin ( as sodium monohydrate ) 250 mg

Hi-flucil vials: Each vial contains:
Amoxycillin ( as sodium ) 500 mg
Flucloxacillin ( as sodium ) 500 mg

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Properties:
Hi-Flucil is penicillinase‑stable broad spectrum antibiotic contains a synergistic combination of two bactericidal antibacterial penicillin drugs:
Amoxycillin, which is a derivative of ampicillin but it's better absorbed than ampicillin when given by mouth, producing higher plasma concentration; unlike ampicillin absorption is not affected by presence of food in the stomach.
Flucloxacillin that is penicillinase resistant penicillin that make this combination active against infections caused by penicillin resistant staphylococci.
Both Amoxycillin and Flucloxacillin diffuse well into body tissues and fluids but penetration into cerebrospinal fluid is poor except when meninges are inflamed.

Indications & usage:
Hi ‑Flucil is indicated in the treatment of infections caused by penicillinase producing staphylococci and non­ penicillinase producing Gram-positive and Gram-negative organisms including streptococci, staphylococci, H. influenzae, Escherichia coli, Enterobacteriaceae and klebsiella such as:
- Respiratory tract infections: pneumonia, chronic bronchitis, emphysema, sinusitis,
otitis media, otitis externa, pharyngitis, tonsillitis and Haemophilus influenzae.
- Genito-urinary tract infections: cystitis, pyelonephritis, prostatitis,
gonorrhea and purpureal sepsis .
- Gastro‑ intestinal infections : Enteritis, bacillary dysentery ,typhoid and
paratyphoid, invasive salmonellosis and Helicobacter pylori eradication.
Skin and soft tissue infections: boils, carbuncles, abscesses, impetigo, cellulitis, anthrax ,post operative wound infections and intra-abdominal abscesses.
Other infections: Septicemia, listerial meningitis ,osteomylitis and prophylaxis against endocarditis

Contra –indications :
Penicillin hypersensitivity.

Side effects:
Hypersensitivity reactions including urticaria, rashes and anaphylaxis.
GIT disturbances: diarrhea, nausea, vomiting and rarely antibiotic- associated colitis.

Warnings & precautions:
Caution is required in the following cases:
History of allergy.
Renal impairment.
Cytomegalovirus infection and lymphocytic leukemia.
Hepatitis and cholestatic jaundice.

Dosage & administration:
Hi-flucil capsules:
Both Amoxycillin and Flucloxacillin is acid stable, well absorbed through G.I.T. It's recommended to take Hi-Flucil capsule in a dose of (500 mg - 1g) every 6- 8 hours at least 30 minutes before food.
N.B. Treatment should be continued for a minimum of 48 - 72 hours after
normal body temperature is re-established.
Hi- flucil vials :
Administration may be I.M ,I .V injection or infusion .
Adults : 500 mg -1 g every 6-8 hours .
Children( 2-10 years ) : ½ adult dose .
Children( under 2 years ): ¼ adult dose .
N.B. For IM injection : dissolve vial in 4 ml water for injection .
For IV injection : dissolve vial in 10 ml water for injection and should be given slowly over 3-4 minutes .

Packing:
Hi-flucil capsules: Box of 8, 16 & (160 Capsules Hospital Pack).
Hi-flucil vials : Box of 1 vial .

Storage:
Store at room temperature (15OC – 25OC), away of reach of children.

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Date: 2010-04-14 | Tags: Hi-flucil | Added by: Modajaa
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 Mohamed Ali Soliman © 2016