Entocid
Tablets
Antidiarrheal & anti-infective Composition:
Each tablet contains:
Di-iodohydroxyquinoline 200 mg.
Phthalyl sulphathiazole 200 mg.
Streptomycin sulphate 200 mg. Properties:
Entocid tablets contains three synergistic components for disinfections of intestinal tract :
Di-iodohydroxyquinoline : Which is effective against the trophozites and cysts of Entameba histolytica located in the large intestine , because it is poorly absorbed from the GIT , the drug can reaches a higher concentration in the intestinal lumen and produces its potent amoebicidal effect precisely at the site of infection.
Phthalyl sulphathiazole : is a sulphonamide with properties similar to sulphamethoxazol , having antibacterial effect in the GIT especially against the Enterobacteriaceae including strains of E. coli, Klebsiella, Proteus, Salmonella, Serratia and few strains of Shigella as well as its effect against protozoa.
Streptomycin sulphate : is an aminoglycoside antibacterial agent which is not absorbed when given by mouth, thus no systemic action or toxicity is produced. However this route of administration is reserved for the local sterilization of the gut .
Entocid components are characterized by being poorly absorbed from GIT thus have local anti-infective effect in GIT. Indications & usage :
Acute and chronic bacillary dysentery.
Amoebiasis.
Bacterial enteritis and colitis. Contra-indications :
Patients with severe renal or hepatic failure or with blood disorders .
Hypersensitivity to Diiodohydroxyquinoline or iodine containing preparations. Side effects :
GIT effects including: nausea, vomiting or abdominal cramps may occur.
Hypersensitivity reactions and skin reactions including urticaria or pruritis may occur . Drug interactions:
Sulphonamides may potentiate effect of some drugs such as oral anticoagulants, methotrexate , phenytoin and sulphonylurea. Warnings & precautions:
Adequate fluid intake is necessary.
Di-iodohydroxyquinoline may cause myelo-optic neuropathy in some patients, especially when used for a long period. Accordingly, the product should not be used for more than 10 consecutive days.
If the patient suffers from blurred vision or visual disturbance, he should tell the doctor who may advise him not to drive the car or operate machine that requires sharp vision.
Children may be likely to develop certain side effects especially if given at high doses for long time.
Caution is required in patients with renal or hepatic impairment or with thyroid disease.
If the patient must have thyroid function test, he should tell the doctor since
Di-iodohydroxyquinoline may interfere with the determination of protein-bound iodine for up to 6 months.
The product is best avoided in patients with neurological disorders.
Safety during pregnancy and in nursing mothers has not been established.
Dosage & administration:
2 tablets initially then one tablet three times daily or as prescribed by the physician . Packing:
A carton box containing 20 or 200 tablets ( 2 or 20 strips of 10 tablets each) . Storage :
Stored in a temperature not exceeding 30 o C.
Keep in dry place ( R.H not exceeding 70 % ) . | 
