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Main » Photo album » Pharmaceuticals photos » Cidolut-Depot
Progestogen preparation

Properties :
Cidolut depot contains 17-alpha- hydroxy - progesterone -17-caproate in an oily solution . Cidolut depot is a clear solution , and may be injected through needles of usual bore. The preparation does not give rise to any inflammation at the site of injection . The duration of action of Cidolut depot is one week.

Indications &usage :
Habitual abortion .
Primary and secondary amenorrhea .
Functional uterine bleeding ( Puberty and preclimacteric bleeding ) .
Polymenorrhoea .

Contra-indications :
§ Undiagnosed vaginal bleeding .
§ Patients with a history or recurrent high risk of arterial disease .
§ Breast or genital carcinoma .
§ Hepatic impairment , especially if it is severe .
§ Diagnostically for pregnancy test .
§ Missed or incomplete abortion .

Drug interactions :
- Enzyme inducing drugs such as carbamazepine , grisofulivin , phenobarbiton ,
phenytoin , and rifampicin may enhances the metabolism and clearance of
progesterone .
- Since hydroxyprogesterone caprote can influence the diabetic control, an
adjustment in anti-diabetic dosage should be required .
- Progesterone may inhibit cyclosporine concentration and increase a risk of
toxicity .

Warnings &precautions :
- Cidolut depot should be used with caution in patients with cardiovascular
diseases or renal impairment , diabetes mellitus , asthma , epilepsy , and
migraine .
- High doses of Cidolut depot should be used with caution in patients susceptible
to thromboembolism .
- Sometimes a local reaction may occur at the site of injection .

- Rarely occurring : coughing , dyspnoea , and circulatory disturbance during
or immediately after injection , but that can be avoided by injecting the drug
very slowly

Dosage & administration:
The high concentration contained in Cidolut depot takes into account
the latest scientific discoveries about corpus luteum therapy. These have
shown that it is often only possible to obtain a successful result using large
doses . Over-dosage of progesterone and its derivatives is practically
speaking not possible .The administration of Cidolut depot is always
indicated if it is desired to obtain a corpus luteum effect extending over at
least one week or longer. This is especially the case in the second half of
the menstrual cycle and during pregnancy .

I-Abortion :
In cases of the tendency to habitual abortion , it is often advisable to administer larger doses of progesterone over a longer time than has either to been usual in order to preserve the pregnancy.
In the tendency of habitual abortion . 125 to 250 mg of Cidolut depot should be injected at weekly intervals for at least the first half of pregnancy

II- Amenorrhea : primary amenorrhea and secondary amenorrhea of relatively long duration:

It is recommended that a cyclical treatment as described by Kaufmann be
carried out over several months . Frequently a spontaneous cycle occurs
subsequently . If this does not take place the treatment must be repeated
over a few months. Using estradiol valerate and Cidolut depot it is found
possible to carry out a cyclically correct treatment in a simple manner. At the beginning of treatment 10mg estradiol valerate are injected intramuscularly. Next either 10mg estradiol valerate are injected on the 14th day as well as 125 mg. Cidolut depot intramuscularly on the 14th and 22nd days or alternatively 10mg estradiol valerate together with 250mg
Cidolut depot intramuscularly on the 18thday of treatment. Following the bleeding which resembles a menstruation and occurs approximately on the 28th day 10mg estradiol valerate intramuscularly are administered and on the 18th day of the artificial cycle 10mg estradiol valerate and 125mg Cidolut depot intramuscularly are given.

III- Functional bleeding :
( Cyclical glandular hyperplasia )
Especially puberty bleeding and pre-climacteric bleeding .
Progesterone has a haemostatic action on the endometrium . the duration of the bleeding and the condition of endometrium are of great significance in the mechanism of this action . Estrogen should be injected simultaneously with : 125mg Cidolut depot - 10 mg Estradiol valerate . A few days later a menstruation like bleeding of limited duration may occur ( medical curettage) . When the bleeding is of long duration the desquamated endometrium should first of all be built up to the stage of proliferation by means of estrogen and then transformed by means of Cidolut depot .

IV- Polymenorrhoea:
In shortening of the phase of secretion, the time of ovulation may be easily determined by regular measurement of the morning temperature.
65 to 125mg of Cidolut depot should be injected intramuscularly between 20th and 22nd days.

Packing :
Box of: one ampoules each of 1 cc containing 125 mg .
Box of : one ampoules each of 1 cc containing 250 mg .

Storage :
Storage at temperature below 30

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Date: 2010-04-14 | Tags: Cidolut-Depot | Added by: Modajaa
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